Association of mixed-exposure to phthalates during pregnancy with birth weight difference between twins
Objective To explore the association between mixed-exposure to phthalates(PAEs)during pregnancy and birth weight difference between twins.Methods A prospective cohort study was conducted.From January 2013 to December 2016,289 women with twin pregnancy from the Wuhan Twin Birth Cohort were recruited.The concentrations of eight PAEs metabolites in the u-rine of pregnant women in the first,second,and third trimesters were measured by high performance liquid chromatography-tandem mass spectrometry.These PAEs included monoethyl phthalate(MEP),monoisobutyl phthalate(MiBP),monobutyl phthalate(MBP),monobenzyl phthalate(MBzP),mono(2-ethylhexyl)phthalate(MEHP),mono(2-ethyl-5-oxohexyl)phthalate(MEO-HP),mono(2-ethyl-5-hydroxyhexyl)phthalate(MEHHP),and mono(2-ethyl-5-carboxypentyl)phthalate(MECPP).Multiple lin-ear regression was used to analyze the relationships between mixed-exposure to these PAEs and weight difference between twins.Quan-tile g-computation and weighted quantile sum regression were used to evaluate the association between mixed-exposure to these PAEs and weight difference between twins.Results The detection rates of all PAEs in urine were more than 80.00％.The highest detection rate was 97.00％for MBP,with a median concentration of 42.08 μg/L throughout the entire pregnancy.The lowest detection rate was 84.43％for MBzP,with a median concentration of 0.46 μg/L over the entire pregnancy.The median of birth weight difference be-tween twins was 210 g.After adjustment for multiple confounders,multiple linear regression showed that the mixed-exposure to MEP,MBP,and MEHP throughout pregnancy was positively associated with the birth weight difference between twins.Weighted quantile sum regression results showed a positive correlation between mixed-exposure to PAEs and birth weight difference between twins during pregnancy.Moreover,quantile g-computation results showed that the birth weight difference between twins increased by 3.88％(95％CI:0.25％-7.64％)with each quartile increase in the mixture of eight PAEs.Conclusion The mixed-exposure to PAEs during the entire pregnancy could increase the birth weight difference between twins.
万方数据
维普
