Objective:To investigate the effect of serum low-density lipoprotein receptor-related protein 5(LRP5)in the pathogenesis of myocardial fibrosis(MF)in patients with type 2 diabetes mellitus(T2DM)complicated with acute myocardial infarction(AMI).Methods:142 patients with AMI admitted to Yanting County People's Hospital in Sichuan Province from March 2021 to November 2023 were enrolled.Among them,45 patients had T2DM and 97 were non-diabetics.Clinical characteristics,serum level of LRP5 expression,cardiac function and degree of MF were compared between the two groups.Pearson correlation was used to analyze the relationship between LRP5 expression level and cardiac function and MF,and univariate logistic regression was performed to determine the effect of LRP5 expression on degree of MF in patients with T2DM and AMI.Results:The proportions of multi-vessel disease and Killip class Ⅲ or Ⅳwere higher,left ventricular ejection fraction(LVEF),stroke volume,cardiac output and E/A ratio were lower,and hyaluronic acid(HA),pro-collagen Ⅰ or Ⅲ,TGF-β1 and MMP-2 were more elevated in diabetic patients with AMI compared to those in non-diabetic AMI patients(all P＜0.05).Serum level of LRP5 expression correlated inversely with LVEF,stroke volume,cardiac output and E/A(r=-0.275,-0.211,-0.242,-0.234,all P＜0.05),but was positively related to HA,pro-collagen Ⅰ or Ⅲ,TGF-β1 and MMP-2 in T2DM patients with AMI(r=0.316,0.332,0.354,0.395,0.366,all P＜0.05).Univariate logistic regression analysis showed that LRP5 was associated with increased HA(OR=1.291),pro-collagen Ⅰ(OR=1.273)or Ⅲ(OR=1.682),TGF-β1(OR=1.935)and MMP-2(OR=1.643)in diabetic AMI patients(P＜0.05).Conclusion:T2DM patients with AMI had lower cardiac function and higher degree of MF compared with non-diabetic AMI patients.An increased expression of LRP5 confers a risk factor for MF in patients with T2DM and AMI.
Low-density lipoprotein receptor-related protein 5Myocardial fibrosisDiabetes mellitusMyocardial infarctionHeart failure
维普
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