Objective:To explore the possible factors related to complications during rotational atherectomy(RA)and major adverse cardiac events(MACE)within 12 months after the procedure.Methods:Clinical data of 316 patients who underwent RA at The First People's Hospital of Yibin and The Third People's Hospital of Yibin from January 2017 to December 2020 were retrospectively collected.Multivariate logistic regression analysis was performed to determine the factors which could influence the occurrence of complications during RA and MACE within 12 months after the procedure.Results:In total,the incidence of complications during RA and MACE within 12 months after the procedure were 15.8%and 22.9%,respectively.Multivariable analysis showed that history of heart failure,SYNTAX score,and vessel to burr diameter ratio were determinants for complications during RA(P<0.05).And,history of hypertension,SYNTAX score,low-density lipoprotein cholesterol(LDL-C)concentration within 6 months,glycosylated hemoglobin(HbA1c),and minimum lumen diameter(MLD)were determinants for MACE within 12 months after the procedure.Conclusion:Intraoperative complications of RA may be related to history of heart failure,SYNTAX score,and burr size.Whereas MACE within 12 months after intervention could be influenced by history of hypertension,SYNTAX score,LDL-C concentration within 6 months,HbA1c,and MLD.