Association analysis of proteins interaction and genes co-regulation
Objective By analyzing 2000 human colon carcinoma related genes and 25189 human biology process related genes from GO database,reveal the association tendency of proteins interaction rate and gene co-regulation intension. Methods Base on 4-dimension codon algorithm,we extracted the mixed models,including genes co-regulation relations and proteins interaction relations. Analyze the enrichment property by hypergeometric distribution,and select the 1073 mixed models that appear frequency greater than or equal to 5 and statistics significance ( P ≤0.05 ). Results There is obvious positive correlation between interacting proteins and co-regulation genes. That is,with the increase of protein interaction rate, the strengthen of co-regulated genes is enhanced. Conclusion Interacting proteins related genes are tend to be co-regulated<英文关键词>=Gene co-regulation strengthen;Protein interaction rate;Interaction tendency
NETL
NSTL
万方数据
维普
