首页|骨性关节炎的遗传学研究进展

骨性关节炎的遗传学研究进展

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骨性关节炎(osteoarthritis,OA)的发病率日益增长,已成为最常见的退行性关节疾病。由于OA的生物学复杂性,对于病因及发病机制还没有完全理解。这篇叙述性综述的目的是重点介绍最近5年发表的OA遗传学的关键研究文章,通过介绍出现的新技术、新方法揭示这些变异基因在OA病因及发病机制中的作用。通过全基因组关联研究(genome wide association study,GWAS)和孟德尔随机化研究(Mendelian randomization, MR)总结OA与其他疾病、常见风险因素的遗传相关性,为OA的诊断、治疗及预防提供新方法。 The incidence of osteoarthritis (OA) is increasing and it has become the most common degenerative joint disease. Due to the biological complexity of OA, the etiology and pathogenesis of OA are not fully understood. The purpose of this narrative review is to highlight the key research articles on OA genetics published in the last 5 years, and to reveal the role of these variants in the etiology and pathogenesis of OA by introducing new technologies and methods. To explore the genetic correlation between OA and other diseases and common risk factors through genome wide association study (GWAS) and Mendelian randomization study (MR), and to provide new methods for the diagnosis, treatment and prevention of OA.
Progress in the genetics study of osteoarthritis
The incidence of osteoarthritis (OA) is increasing and it has become the most common degenerative joint disease. Due to the biological complexity of OA, the etiology and pathogenesis of OA are not fully understood. The purpose of this narrative review is to highlight the key research articles on OA genetics published in the last 5 years, and to reveal the role of these variants in the etiology and pathogenesis of OA by introducing new technologies and methods. To explore the genetic correlation between OA and other diseases and common risk factors through genome wide association study (GWAS) and Mendelian randomization study (MR), and to provide new methods for the diagnosis, treatment and prevention of OA.

OsteoarthritisGeneticsEpidemiology

杨芳军、王富洋、谢银银、张倩、杨存恒、温剑涛

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甘肃省中医院骨科,兰州 730050

大连大学附属中山医院骨科,大连 116001

重庆市开州区人民医院普外科,重庆 405400

湖北省恩施土家族苗族州中心医院肾病科,恩施 445000

首都医科大学附属宣武医院神外六科,北京 100053

甘肃省中医院小儿脊柱外科,兰州 730050

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骨性关节炎 遗传学 流行病学

甘肃省联合科研基金重大项目甘肃省自然科学基金

23JRRA152922JR5RA632

2024

国际遗传学杂志
中华医学会 哈尔滨医科大学

国际遗传学杂志

影响因子:0.175
ISSN:1673-4386
年,卷(期):2024.47(1)
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