摘要
在OCT的视网膜和脉络膜层中存在一些生物标志物,高反射点(HRS)最为突出,它被定义为边界清晰、后方无伪影、直径≤30μm、反射率≥RPE层的小亮点.其来源至今尚无确切答案,越来越多的证据表明高反射点的组织病理学相关因素不是单一的,与迁移的视网膜色素上皮细胞、富含脂质的巨噬细胞、小胶质细胞和渗出的蛋白质或脂质物质有关.本文从高反射点的影像学特征、临床特征和临床治疗方面进行综述.(国际眼科纵览,2024,48:64-68)
Abstract
Among the retina and choroid layers in OCT,many biomarkers have been found,and hy-perreflective retinal spots(HRS)are the most prominent.It is defined as a small bright spot with a clear boundary,no posterior projection,a diameter of less than or equal to 30 μm,and a reflectivity greater than or equal to that of the RPE layer.Its origin has not been precisely determined.Increasing evidence shows that the histopathological correlates of HRS are not singular,and there is a relationship between migrating retinal pigment epithelium cells,lipophilic macrophages,microglia,and exudative protein or lipid sub-stances.This article reviews the imaging characteristics,clinical characteristics,and clinical treatment of HRS.(Int Rev Ophthalmol,2024,48:64-68)
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