Characterization and clinical significance of hyperreflective retinal spots as OCT biomarkers in reti-nal diseases
Among the retina and choroid layers in OCT,many biomarkers have been found,and hy-perreflective retinal spots(HRS)are the most prominent.It is defined as a small bright spot with a clear boundary,no posterior projection,a diameter of less than or equal to 30 μm,and a reflectivity greater than or equal to that of the RPE layer.Its origin has not been precisely determined.Increasing evidence shows that the histopathological correlates of HRS are not singular,and there is a relationship between migrating retinal pigment epithelium cells,lipophilic macrophages,microglia,and exudative protein or lipid sub-stances.This article reviews the imaging characteristics,clinical characteristics,and clinical treatment of HRS.(Int Rev Ophthalmol,2024,48:64-68)
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