TGF-β通路相关的后发性白内障发生机制
The impact of regulatory factors on the TGF-β pathway on posterior capsule opacification
徐素 1张宇航 1司玮 1张凤妍1
作者信息
- 1. 郑州大学第一附属医院眼科,郑州 450000
- 折叠
摘要
后发性白内障(posterior capsule opacification,PCO)是导致白内障患者术后视觉质量不佳的主要原因,在成年人术后发生率为30％～50％,在儿童中则高达100％.PCO的发病机制复杂,TGF-β通路影响了晶状体上皮细胞的上皮-间质转化及迁移,部分核糖核酸的表达、自噬或凋亡的发生均可通过调控TGF-β通路进而影响PCO形成,并可由此发掘可能预防PCO的潜在药物.(国际眼科纵 览.2024.48:87-92)
Abstract
Posterior capsule opacification(PCO)is the primary cause of compromised visual acuity in patients following cataract surgery,with an incidence ranging from 30％to 50％in adults and up to 100％in children.The pathogenic mechanism of PCO is complex.The TGF-β pathway influences the epithelial-mesenchymal transition and migration of lens epithelial cells.The expression of certain ribonucleic acids,autophagy or apoptosis can exert influence on PCO formation,thereby leading to the identification of potential therapeutic agents for its prevention.(Int Rev Ophthalmol,2024,48:87-92)
关键词
后发性白内障/转化生长因子β/晶状体Key words
posterior capsule opacification/transforming growth factor beta/lens引用本文复制引用
出版年
2024
NETL
NSTL
万方数据