The relationship between inwardly rectifying potassium channels and retinopathy
Inwardly rectifying potassium(Kir)channels,a subclass within the potassium channel family,are extensively distributed in a variety of tissue cells and play a vital role in maintaining bodily home-ostasis.Recent research indicates their presence in the retinal pigment epithelium,neurons,glial cells,and vascular cells.These channels are instrumental in preserving retinal osmotic balance,combating neurotoxic and oxidative stress,and facilitating visual processing.Kir channels have been implicated in the progression of several retinal diseases,including diabetic retinopathy,hereditary KCNJ13-related retinal disorders,and glaucoma.(Int Rev Ophthalmol,2024,48:123-128)
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