摘要
外泌体是一种由细胞分泌的具有磷脂双分子层膜结构的囊泡小体,携带蛋白质、DNA、mRNA、小RNA、脂质等生物信号分子,是细胞间的通讯媒介.外泌体在肿瘤侵袭转移、化学耐药、血管新生、免疫逃逸等众多病理过程中发挥重要作用.近年来研究发现,外泌体存在于脉络膜黑色素瘤和视网膜母细胞瘤患者的血清、玻璃体、肿瘤组织及体外培养的肿瘤细胞系中,参与两种肿瘤的转移及恶变.(国际眼科纵览,2024,48:151-155)
Abstract
Exosome,a kind of small vesicle enclosed by a phospholipid bilayer,is secreted by cells.Exosomes carry many biological molecules,such as protein,DNA,mRNA,miRNA,lipid,which are mediators of intercellular communication.Exosomes play an important role in many tumor pathological processes such as invasion and metastasis,chemical resistance,angiogenesis,and immune escape.Recent studies have found that exosomes exist in the serum,vitreous body,tumor tissue and tumor cell lines cul-tured in vitro of patients with uveal melanoma(UM)and retinoblastoma(RB),and are involved in the me-tastasis and malignancy of these two tumors.(Int Rev Ophthalmol,2024,48:151-155)
基金项目
国家自然科学基金(82003794)
深圳市科创委基础研究基金(JCYJ20190808170609490)
NETL
NSTL
万方数据