The relationship between exosomes and intraocular malignant tumor metastasis
Exosome,a kind of small vesicle enclosed by a phospholipid bilayer,is secreted by cells.Exosomes carry many biological molecules,such as protein,DNA,mRNA,miRNA,lipid,which are mediators of intercellular communication.Exosomes play an important role in many tumor pathological processes such as invasion and metastasis,chemical resistance,angiogenesis,and immune escape.Recent studies have found that exosomes exist in the serum,vitreous body,tumor tissue and tumor cell lines cul-tured in vitro of patients with uveal melanoma(UM)and retinoblastoma(RB),and are involved in the me-tastasis and malignancy of these two tumors.(Int Rev Ophthalmol,2024,48:151-155)
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