Research progress of stem cell exosomes in treatment of glaucoma
Glaucoma is a group of diseases characterized by characteristic optic atrophy.Its patho-logical manifestations are the damage and apoptosis of retinal ganglion cells.Stem cell exosomes are extracel-lular microvesicles released by stem cells,which not only retain the function of stem cells in promoting the regeneration and repair of damaged retinal ganglion cells,but also mitigatethe side effects of stem cells,and therefore have become a substitute for stem cells.In addition,stem cell exosomes can also induce the prolif-eration of trabecular meshwork cells and promote aqueous humor outflow;and it can be used as a drug carrier of anti-scarring drug aptamer S58 in anti-glaucoma surgery,delaying the degradation of S58 and significantly enhancing the duration of its anti-scarring effect.Based on the biological characteristics and functions of exo-somes.The research progress of exosomes in glaucoma treatment puts forward that exosomes secreted by stem cells have broad application prospects in glaucoma treatment.(Int Rev Ophthalmol,2024,48:177-183)
NETL
NSTL
万方数据
