干细胞外泌体治疗青光眼的研究进展
Research progress of stem cell exosomes in treatment of glaucoma
吕佳谚 1付强 2蔄雪静3
作者信息
- 1. 滨州医学院烟台附属医院,山东烟台 264000
- 2. 滨州医学院药学院,山东烟台 264000
- 3. 烟台毓璜顶医院,山东烟台 264000
- 折叠
摘要
青光眼是一组以特征性视神经萎缩为主要特征的疾病,主要病理表现为视网膜神经节细胞的损伤和凋亡.干细胞外泌体是干细胞释放的细胞外微囊泡,既保留了干细胞促进受损神经节细胞再生和修复的功能,还避免了干细胞的副作用,从而可成为干细胞的替代品.此外,干细胞外泌体还可诱导小梁网细胞增生促进房水外流,并在抗青光眼手术中可作为抗瘢痕化药物适体S58的药物载体,延缓S58的降解,显著增强其抗瘢痕化的作用时长.干细胞外泌体在青光眼治疗方面有着广阔的应用前景.(国际眼科纵览,2024,48:177-183)
Abstract
Glaucoma is a group of diseases characterized by characteristic optic atrophy.Its patho-logical manifestations are the damage and apoptosis of retinal ganglion cells.Stem cell exosomes are extracel-lular microvesicles released by stem cells,which not only retain the function of stem cells in promoting the regeneration and repair of damaged retinal ganglion cells,but also mitigatethe side effects of stem cells,and therefore have become a substitute for stem cells.In addition,stem cell exosomes can also induce the prolif-eration of trabecular meshwork cells and promote aqueous humor outflow;and it can be used as a drug carrier of anti-scarring drug aptamer S58 in anti-glaucoma surgery,delaying the degradation of S58 and significantly enhancing the duration of its anti-scarring effect.Based on the biological characteristics and functions of exo-somes.The research progress of exosomes in glaucoma treatment puts forward that exosomes secreted by stem cells have broad application prospects in glaucoma treatment.(Int Rev Ophthalmol,2024,48:177-183)
关键词
青光眼/干细胞/外泌体Key words
glaucoma/stem cells/exosomes引用本文复制引用
基金项目
山东省自然科学基金(ZR2023MH262)
出版年
2024
NETL
NSTL
万方数据