Roles of ferroptosis in the pathogenesis of cataract
Previous studies have shown that cataractous lenses exhibit characteristics of ferroptosis,including increased levels of oxidatively active iron,elevated lipid peroxidation,and a disrupted glutathione peroxidase system.Recent researches have confirmed that epithelial cells from age-related cataract lenses un-derwent ferroptosis.The use of agents like astaxanthin and melatonin can delay cataract formation by inhibi-ting the ferroptosis pathway.Additionally,the levels of lipid peroxidation and oxidative active iron in high myopia-associated cataracts have been found to be higher than those in age-related cataracts.(Int Rev Oph-thalmol,2024,48:200-204)
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