The relationship between Wnt/β-catenin signaling pathway and the pathogenesis of myopia
The etiology of myopia involves a complex regulatory process of the retina-choroid-sclera axis,wherein the Wnt/β-catenin pathway plays a pivotal role as a significant signaling pathway in myopia development.Studies indicate that activation of the Wnt/β-catenin pathway correlates positively with the se-verity of myopia,and inhibiting this pathway may potentially slow the progression of myopia.Moreover,indi-viduals with myopia exhibit significantly reduced levels of DKK-1(Dickkopf-1)in their blood,and supple-mentation of DKK-1 may mitigate axial elongation of the eye and progression of myopia.These findings pave the way for novel research directions in therapeutic strategies based on the Wnt/β-catenin pathway.(Int Rev Ophthalmol,2024,48:433-437)
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