Progress on oxidative stress of trabecular meshwork cells in primary open-angle glaucoma
Primary open-angle glaucoma(POAG)is the most common type of glaucoma,while its pathogenesis remains elusive.In recent years,oxidative stress has been recognized as the critical role in PO-AG formation and progress.Specifically,excessive reactive oxygen species promote the pathogenesis of tra-becular meshwork(TM),and lead to the dysfunction of aqueous humor outflow pathway,as well as intraoc-ular pressure elevation.However,the relationship between oxidative stress and TM dysfunction is not fully understood yet.In this article,we aim to elucidate the mechanisms underlying oxidative stress-induced TM damage in POAG,including the oxidative stress sources,the responsive molecular mechanisms of TM cells exposure to oxidative stress,and the structural and functional changes of TM.(Int Rev Ophthalmol,2024,48:448-453)
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