Research advances of retinal glial cells involved in glaucomatous optic neuropathy
Retinal glial cells,considered as vital immunoregulatory cells,sparked widespread en-thusiasm for studying on the mechanism of glaucomatous optic nerve damage via glial cell-driven neuroinflam-matory response.In recent years,the important role and molecular mechanism of different types of retinal glial cells such as microglia,astrocytes and Müller cells in glaucoma progression have been gradually re-vealed.The activation of retinal glial cells is an early event of glaucomatous optic nerve damage,which oc-curs before the loss of retinal ganglion cells and is regarded as the"trigger"of retinal neuroinflammation.In this review,we make a preliminary sketch of the latest studies from the aspects of microglia,astrocytes,Müller cells and their crosstalk,thereby providing a reference for the molecular mechanism of retinal glial cells involved in glaucomatous optic nerve damage and the formulation of potential targeted treatment strate-gies.(Int Rev Ophthalmol,2024,48:454-459)
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