Relationship between clinical efficacy and blood concentrationof second-generation antipsychotics in patients with schizophrenia
Schizophrenia is a life-long illness requiring indefinite maintenance and antipsychotic treatment.Second-generation antipsychotics are believed to have a superior effect on the positive,negative and cognitive symptoms of schizophrenia.However,some drugs may show high interindividual variability in blood levels.This review summarizes the relationship between the total blood concentration or active metabolite plasma level of second-generation antipsychotics and their efficacy,in order to find the optimal blood concentration.The results vary largely among the positive results,and limited evidence from fixed-dose studies is encouraging.More well-designed trials with large samples are needed to clarify the optimal blood concentration of antipsychotics.
NETL
NSTL
万方数据
维普
