Correlation between iodine status and hypothyroidism among women in early pregnancy
Objective To investigate the iodine status among women in early pregnancy in Gansu Province, and to explore the relationship between iodine nutrition and hypothyroidism.Methods A total of 200 women in early pregnancy undergoing routine prenatal examination during Feb.2015 and May 2016 were selected.The urine iodine, serum thyroid stimulating hormone (TSH) and free thyroxine (FT) levels were measured with spectrophotometry.Results The urine iodine was 8.2~1 857.8 mg/L, median 178.3 mg/L.Iodine deficiency was observed in 79 women (39.5%).Abnormal urine iodine was observed in 121 women (60.5%).There was significant difference in TSH among women with different urine iodine levels (P<0.05), but there was no significant difference in FT (P>0.05).The incidence of hypothyroidism in women with abnormal iodine intake was 7.1% (9/126), which was significantly higher than that in women with normal iodine intake[1.4% (1/74)], with statistical difference (χ2=3.661, P<0.05).Conclusions The iodine intake of women in the early stage of pregnancy in Zhuanglang County is generally insufficient.Iodine deficiency still exists.Different iodine intakes can significantly affect thyroid hormone levels and may be an important cause of hypothyroidism.
early pregnancythyroid functioniodine nutritionhypothyroidism
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