The effect of montelukast combined with seretide on the cellular immunity and trace elements in children with bronchial asthma
Objective To explore the clinical curative effect of Montelukast combined with Seretide for children with bronchial asthma and the effect on the cellular immunity and trace elements.Methods A total of 60 children with bronchial asthma treated during June 2015 and Feb.2017 were randomly divided into 2 groups: control group (n=30) treated with Seretide, and combined group (n=30) treated with montelukast plus Seretide.The curative effect, changes of pulmonary function, immunity function and trace elements were compared between the 2 groups before and after treatment.Results After treatment, the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and peak expiratory flow rate (PEF) of all patients significantly increased (P<0.05), and the indexes were significantly higher in the combined group than in the control group (P<0.05).The total effective rate was higher in the combined group than in the control group (P<0.05).The serum IFN-γ level of all patients increased remarkably after treatment (P<0.05), and the level was significantly higher in the combined group than in the control group (P<0.05).The IL-13 level of all patients decreased after treatment (P<0.05), and it was significantly lower in the combined group than in the control group (P<0.05).The contents of Cu, Ca, Fe, Mg, Cu and Zn of both groups increased significantly after treatment (P<0.05), and the elements content were remarkably higher in the combined group than in the control group (P<0.05).Conclusions Montelukast combined with Seretide not only produces good curative effect for children with bronchial asthma, but also improves the pulmonary and immunity function, which may contribute to the balance of trace elements.
bronchial asthmachildrenmontelukastseretideimmunitytrace elements
NETL
NSTL
万方数据
