Correlation between the expression of macrophage inflammatory protein-1α and prognosis in patients with acute myeloid leukemia
Objective To investigate the relationship between the expression of macrophage inflammatory protein-1α(MIP-1α) and prognosis in patients with acute myeloid leukemia (AML).Methods Used a retrospective study, 96 patients with acute myeloid leukemia were treated in our hospital from February 2012 to August 2016 were selected as the observation group, At the same time, 96 cases of the adult healthy volunteers in our hospital were selected as the control group.Two groups were tested for the expression of MIP-1α.The clinical features and prognosis of the patients in the observation group were investigated.Results The relative expression of MIP-1αmRNA in the observation group and the control group were 2.94±0.55 and 0.78±0.64 that the observation group was significantly higher than that of the control group (P<0.05).In the observation group, the relative expression of MIP-1 mRNA were significantly different in different immune type and karyotype (P<0.05), and there were no significant difference in sex, age, body mass index (P>0.05).Patients in the observation group were followed up to now, 72 cases were survival,the survival rate was 75%.The relative expression level of MIP-1α mRNA in survival patients was 1.87±0.52, which was significantly lower than that of the death patients of 4.83±0.72(t=7.398,P<0.05).Multivariate Cox regression analysis showed that the immunophenotype, karyotype and MIP-1αmRNA were independent risk factors for the prognosis of patients with acute myeloid leukemia (P<0.05).Conclusion The expression of MIP-1α in patients with acute myeloid leukemia is highly, it is correlated with the immunophenotype, karyotype and prognosis of patients, and it is the main independent risk factor for influencing the prognosis of patients.
acute myeloid leukemiaMIP-1αprognosiscorrelationclinical features
NETL
NSTL
万方数据
维普
