Clinical significance of combined detection of GPI, anti-CCP and RF in the diagnosis of rheumatoid arthritis
Objective To investigate the clinical significance of combined detection of GPI, anti-CCP and RF in the diagnosis of rheumatoid arthritis.Methods A total of 120 cases of rheumatoid arthritis treated in our hospital during Jan.2012 and Dec.2016 were selected as group A;100 cases of other autoimmune diseases, including osteoarthritis, systemic lupus erythematosus, primary Sjogren`s syndrome, systemic sclerosis and mixed connective tissue disease served as group B;100 healthy controls served as group C.The GPI and anti-CCP were detected with ELISA, and serum RF was measured with immune turbidimetry.The positive rate, specificity, sensitivity, negative predictive value and positive predictive value were compared.Results The positive rate of GPI, anti-CCP, RF and combined detection in group A were significantly higher than those in group B and C (P<0.05).The specificity, sensitivity, negative predictive value and positive predictive value of combined detection of GPI, anti-CCP and RF were significantly higher than those of single detection (P<0.05).Conclusion GPI, anti-CCP and RF have higher positive expression rate in rheumatoid arthritis, and combined detection can improve the detection rate of rheumatoid arthritis.
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