Application of thin-cytologic test and human papilloma virus detection in the screening of cervical cancer screening
Objective To investigate the applicative value of thin-cytologic test (TCT) and human papilloma virus (HPV) detection in the screening of cervical cancer.Methods A total of 200 cervical cancer cases treated during 2013 and 2016 were selected.All patients received TCT and HPV tests.Those with positive underwent biopsy of cervical tissues.Results Of the 200 cases, 195 were TCT positive.With the increase of cytological classification, the accuracy rate of histological examination increased.Altogether 52 cases were HPV positive, of which 33 were inflammatory (63.46%) and 18 (34.62%) were cervical intraepithelial neoplasias (CIN).Compared with the accurate rate of TCT (77.21%), the difference was statistically significant (P<0.05).According to the presence of HPV infection, 102 cases of atypical squamous cell of undermined significance (ASCUS) were divided into 2 groups: HPV positive (n=52), 38 of which were confirmed as CIN, accurate rate 73.08%, and HPV negative (n=50), of which 14 were confirmed as CIN, accurate rate 28%, with significant difference (P<0.05).With the increase of severity, the HPV infection rate increased.Conclusion Patients with ASCUS can first have HPV DNA testing.If the test result is positive, colposcopic biopsy must be performed immediately.If the result is negative, cytology or HPV detection are recommended.These measures can improve the detection rate of cervical cancer and reduce the medical costs.
cervical cancer screeningthin-cytologic testhuman papilloma virus detectionapplication
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