Research advances of gene polymorphism of renin-angiotensin-aldoster one system and essential hypertension
Essential hypertension (EH) is a polygenic disorder that results from inheritance of a number of susceptibility genes and involves multiple environmental determinants.These determinants complicate the study of blood pressure variations in the general population.Since the first susceptibility gene study was reported in 1992, EH has attracted numerous studies to identify the genetic basis.The renin-angiotensin-aldosterone system (RAAS) may play a prominent role in the genesis of hypertension.Polymorphisms of the genes coding for angiotensinogen, angiotensin-converting enzyme, angiotensin Ⅱ type I receptor, and aldosterone syntheses are widely studied.The review first summarizes the relationship between the four genes polymorphism and EH, and then introduces the gene-gene interaction and gene-environment interaction.Although susceptibility genetic studies have improved our understanding for the molecular basis of EH, the relationship between the genes polymorphism and EH is still controversial due to genetic heterogeneity, racial differences and so on.
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