Syntheses of N-substituted gardenamide A derivatives
Objective To investigate the synthesis of N-substituted gardenamide A derivatives.Methods Genipin was used as starting material,and all the target compounds were prepared through the selective protection of 10-hydroxyl group,the selective oxidation of 1-semiacetal,and the lactamization when reacted with amines.Results Eight N-gardenamide A derivatives were synthesized via a three-step process.The yields for each steps were 89％,80％,and 22％-44％ respectively.Conclusion Three-step process for the synthesis of N-substituted gardenamide A derivatives is concise.However,the yield for the last step needs to improve.
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