慢性阻塞性肺疾病稳定期炎症生物标志物与肺功能的相关性
The Correlation between Inflammatory Biomarkers and Lung Function in COPD Stable Phase
原源 1邓晓慧 1岳睿 1葛晓竹 1汪薇 1田巍1
作者信息
- 1. 首都医科大学附属北京积水潭医院老年医学科,北京 100035
- 折叠
摘要
目的 探讨慢性阻塞性肺疾病(COPD)稳定期患者白细胞介素(IL)-1家族、经典炎症标志物与肺功能的相关性.方法 选取2021年7月-2022年12月在首都医科大学附属北京积水潭医院老年医学科门诊就诊或病房住院的45例COPD稳定期患者进行前瞻性横断面调查研究,收集性别、年龄、吸烟史及吸烟指数、基础疾病信息,进行血清IL-1家族(IL-lα、IL-1 β、IL-18)、IL-6、IL-8、TNF-α检测及肺功能检查.结果 多元线性回归分析显示,与第1秒用力呼气容积(FEV1)预计值占比(FEV1％)独立相关的炎症标志物是IL-18,与肺一氧化碳弥散量(DLCO)独立相关的是IL-18和年龄,与FEV1改善率独立相关的是IL-18.结论 COPD稳定期的IL-18水平与肺通气功能、肺弥散功能及FEV1改善率均显著相关,提示IL-18在该阶段的疾病发生发展中可能发挥了重要作用,可作为COPD稳定期病情评估的良好监测指标.
Abstract
Objective To investigate the correlation between interleukin(IL)-1 family,classical inflammatory markers and pulmonary function in patients with stable chronic obstructive pulmonary disease(COPD).Methods Forty-five patients with stable COPD who visited the outpatient clinic or ward of the Department of Geriatrics,Beijing Jishuitan Hospital,Capital Medical Uni-versity,from July 2021 to December 2022 were selected for a prospective cross-sectional survey to collect gender,age,smoking his-tory and smoking index,underlying disease information,and serum IL-1 family(IL-1α,IL-1β,IL-18),IL-6,IL-8,TNF-α detection and pulmonary function tests.Results Multivariate regression analysis found that IL-18 was independently corre-lated with forced expiratory volume in the first second(FEV1)predicted value(FEV1％),IL-18 and age were independently asso-ciated with the single-breath diffusing lung capacity of carbon monoxide(DLCO),IL-18 was independently related to the improve-ment rate of FEV1.Conclusion IL-18 level in stable COPD was significantly correlated with pulmonary ventilation function,pul-monary diffusion capacity and FEV1 improvement rate,which suggesting that IL-18 may play an important role in the development of the disease at this stage and can be used as the good monitoring indicators for the evaluation of stable COPD.
关键词
慢性阻塞性肺疾病/稳定期/白细胞介素-1家族/炎症因子/肺功能Key words
Chronic obstructive pulmonary disease/Stable phase/IL-1 family/Inflammatory factors/Pulmonary func-tion引用本文复制引用
基金项目
北京市市属医院科研培育项目(PZ2021004)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据