中药复方治疗糖尿病合并失眠随机对照试验的Meta分析
Meta-analysis of Randomized Controlled Trials of Chinese Herbal Compound in the Treatment of Diabetes Mellitus Complicated with Insomnia
王钦 1刁丽梅 1姚春园 1陈江玮 1刘金文1
作者信息
摘要
目的 系统评价中药复方治疗糖尿病合并失眠随机对照试验的临床有效性和安全性.方法 检索医学数据库CNKI、VIP、万方、PubMed、EMBase、The Cochrane Library,收集并评价截至2023年2月的符合纳入标准的随机对照试验研究,并根据治疗有效率、匹兹堡睡眠指数(PSQI)量表评分、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2hPBG)等结局指标提取并分析相关数据,Meta分析采用Review Manager 5.4软件进行.结果 共13篇文献符合标准,总计纳入病例1 183例,其中实验组599例,对照组584例.Meta分析结果表明中药复方组在干预后的治疗有效率、PSQI量表评分以及FPG、HbA1c、2hPBG水平均优于西药对照组.结论 Meta分析结果提示中药复方改善糖尿病合并失眠的作用优于西药.
Abstract
Objective To systematically evaluate the clinical efficacy and safety of Chinese herbal compound in the treat-ment of diabetes with insomnia in a randomized controlled trial.Methods The medical databases CNK1,VIP,Wanfang,PubMed,EMBase,and The Cochrane Library were searched to collect and evaluate randomized controlled trial studies that met the inclusion cri-teria as of February 2023,and relevant data were extracted and analyzed according to outcome measures such as treatment response rate,Pittsburgh sleep quality index(PSQI)scale score,fasting plasma glucose(FPG),hemoglobin A1e(HbA1c),and 2 h post-prandial blood glucose(2hPBG).Meta-analysis was performed using Review Manager 5.4 software.Results Thirteen articles met the criteria,and a total of 1 183 cases were included,including 599 cases in the experimental group and 584 cases in the control group.Meta-analysis showed that the treatment response rate,PSQI scale score,FPG,HbA1c and 2hPBG levels in the Chinese herbal compound group were better than those in the Western medicine control group after intervening diabetic patients with insomnia.Conclusion Meta-analysis results suggest that Chinese herbal compound is superior to western medicine in improving diabetes with insomnia.
关键词
中医药/中药复方/糖尿病合并失眠/Meta分析Key words
Traditional Chinese Medicine/Chinese herbal compound/Diabetes with insomnia/Meta-analysis引用本文复制引用
基金项目
国家自然科学基金(81960858)
广西中医脑病临床研究中心项目(桂科AD20238028)
广西科技基地和人才专项(2021AC18028)
广西壮族自治区高等学校高水平创新团队及卓越学者计划(桂教人才[2020]6号)
广西中医药大学第一附属医院学术团队建设项目(院字[2018]146号)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据