摘要
抑郁症和肌少症是老年人中常见的两种疾病,抑郁症患者因情绪低落、久坐少动等原因可引发肌少症,肌少症因肌肉质量及功能下降,患者缺乏与社会接触及沟通,患抑郁症风险增加.运动缺乏、营养不良、氧化应激及炎症反应等可能是两者的共同发病机制.本文就抑郁症与肌少症的发病机制和治疗的进展作一综述.
Abstract
Depression and sarcopenia represent prevalent conditions among the elderly.The interplay between these two ail-ments is noteworthy,as depression can contribute to sarcopenia through factors such as diminished mood,sedentary lifestyles,and re-duced physical activity.Conversely,sarcopenia is linked to decreased muscle mass and function,limited social interactions,and an elevated risk of depression.Recent research has unveiled a correlation between these conditions,highlighting shared pathogenic ele-ments including exercise deficiency,malnutrition,oxidative stress,and inflammation.This article provides a comprehensive review of advancements in understanding the pathogenesis and treatment modalities for both depression and sarcopenia.By examining the in-tricate connections between these conditions,it offers valuable insights into potential shared therapeutic interventions and sheds light on holistic approaches to address the complex interplay of depression and sarcopenia in the elderly.
基金项目
国家自然科学基金青年科学基金(82101652)
重庆市自然科学基金而上项目(cstc2021jcyjmsxmX0207)
国家科技期刊平台
NSTL
维普
万方数据