细胞焦亡在肌少性肥胖中的作用机制及研究进展
Advancements in Understanding the Molecular Mechanisms of Pyroptosis in Sarcopenic Obesity:a Comprehensive Research Overview
付婉瑞 1古再丽努尔·卡德尔 2何雅琦 2冯颖2
作者信息
- 1. 复旦大学附属华东医院上海市老年医学临床重点实验室 200040
- 2. 复旦大学附属华东医院营养科,上海 200040
- 折叠
摘要
随着全球老龄化与肥胖人群的增加,肌少性肥胖(SO)引起了越来越多的关注.焦亡是一种新近发现的细胞炎性死亡方式,特征是炎症小体的激活以及大量促炎因子的释放.近期研究发现,细胞焦亡在SO的发生与发展中起着重要作用,充分阐明SO中的焦亡途径有助于明确SO的发病机制并挖掘其潜在的治疗靶点,本文拟对焦亡的分子机制,焦亡在肥胖、肌少症和SO中的作用机制作一综述,为SO的治疗提供新的思路.
Abstract
In an era of global population aging and a rising prevalence of obesity,the complex condition known as sar-copenic obesity(SO)has emerged as a subject of growing interest and concern.A relatively recent discovery,pyroptosis,a form of programmed cell death characterized by the activation of inflammasomes and the subsequent release of a multitude of inflammatory me-diators,has garnered increasing attention.Emerging research suggests that pyroptosis plays a pivotal role in the intricate development and progression of SO.Understanding the intricate relationship between SO and pyroptosis holds the potential to shed light on the un-derlying mechanisms driving SO's pathogenesis.Such insights not only contribute to a deeper comprehension of SO but also offer valua-ble guidance for the development of targeted therapeutic interventions.
关键词
肌少性肥胖/焦亡/肥胖/肌少症/衰老Key words
Sarcopenic obesity/Pyroptosis/Obesity/Sacorpenia/Aging引用本文复制引用
基金项目
上海市卫生健康系统重要薄弱学科建设计划(2019ZB0102)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据