Objective To explore the correlation between the expression of long non-coding RNA(lncRNA)UCA1 and radiotherapy sensitivity in patients with esophageal squamous cell carcinoma.Methods A total of 80 patients with esophageal squa-mous cell carcinoma admitted to the Affiliated Tumor Hospital of Xinjiang Medical University from February 2020 to February 2022 were selected as the esophageal cancer group,and 50 subjects who underwent health examinations in our hospital during the same peri-od were selected as the control group.Real time fluorescence quantitative PCR was used to detect the plasma lncRNA UCA1 expres-sion levels of all subjects and compare them.The relationship between lncRNA UCA1 levels and clinical pathological indicators in e-sophageal cancer patients,as well as their relationship with radiation sensitivity,was analyzed.Results The plasma lncRNA UCA1 levels in the esophageal cancer group were higher than those in the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in plasma lncRNA UCA1 levels among patients of different genders,ages,and lymph node metastases or not(P＞0.05);The plasma lncRNA UCA1 levels in patients with TNM stage Ⅲ+Ⅰ esophageal squamous cell carcinoma were higher than those in patients with stage Ⅰ+Ⅱ,and the difference was statistically significant(P＜0.05).After dividing plasma lncRNA UCA1 levels into three equal parts,logistic regression was used to analyze the relationship between plasma ln-cRNA UCA1 levels and radiotherapy sensitivity for esophageal squamous cell carcinoma.The results showed that after multiple factor adjustment,compared with patients in the low-level group(plasma lncRNA UCA1 levels＜0.12),patients in the moderate level group(plasma lncRNA UCA1 levels ranging from 0.12 to 0.23)and the high-level group(plasma lncRNA UCA1 levels＞2.31)showed a significant decrease in radiotherapy sensitivity(P＜0.05).Conclusion Plasma lncRNA UCA1 is an independent influen-cing factor in predicting the radiotherapy sensitivity of esophageal squamous cell carcinoma patients,which helps to early predict the radiotherapy sensitivity of esophageal squamous cell carcinoma patients in clinical practice and provides new ideas and goals for the treatment of esophageal squamous cell carcinoma.
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