摘要
转移是晚期胃癌患者的主要表现及治疗失败的主要原因.部分胃癌转移相关因子通过对上皮间充质转化、黏附、迁移、侵袭、增殖、血管生成等过程的调控促进或抑制胃癌转移.本文拟对胃癌转移相关因子对胃癌转移过程不同阶段的作用及潜在分子机制作一综述,明确其调控胃癌转移的机制及潜在的治疗靶点,为胃癌转移提供新的检测手段及治疗选择.
Abstract
Metastasis is the main manifestation of advanced gastric cancer patients and the main cause of treatment failure.Some gastric cancer metastasis related factors promote or inhibit gastric cancer metastasis by regulating epithelial-mesenchymal transi-tion,adhesion,migration,invasion,proliferation and angiogenesis.This article aims to provide a view of the effects and potential molecular mechanisms of gastric cancer metastasis related factors in different stages of gastric cancer metastasis,clarify their mecha-nisms of regulating gastric cancer metastasis and potential therapeutic targets,provide new detection methods for gastric cancer metas-tasis and new treatment options for patients with metastasis gastric cancer.
维普
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