国际老年医学杂志2024,Vol.45Issue(3) :344-347.DOI:10.3969/j.issn.1674-7593.2024.03.017

同型半胱氨酸、叶酸及维生素B12与非酒精性脂肪性肝病的研究进展

Studies on the Relationship between Nonalcoholic Fatty Liver Disease and Homocysteine,Folic Acid and Vitamin B12

张玉滢 马璐瑶 柳思琪 金珍婧
国际老年医学杂志2024,Vol.45Issue(3) :344-347.DOI:10.3969/j.issn.1674-7593.2024.03.017

同型半胱氨酸、叶酸及维生素B12与非酒精性脂肪性肝病的研究进展

Studies on the Relationship between Nonalcoholic Fatty Liver Disease and Homocysteine,Folic Acid and Vitamin B12

张玉滢 1马璐瑶 1柳思琪 1金珍婧1
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作者信息

  • 1. 吉林大学白求恩第二医院,长春 130022
  • 折叠

摘要

非酒精性脂肪性肝病(NAFLD),是全球最常见的肝病,与胰岛素抵抗、肥胖和代谢综合征密切相关.随着年龄的增加,高血压、高血脂、糖代谢异常等代谢疾病的发病率逐渐升高,而NAFLD通常因无症状而易被忽视,因此,寻找早期有效的诊断指标对遏制疾病的发展十分必要.同型半胱氨酸是许多慢性疾病发生的危险因素,如心血管疾病、糖尿病、NAFLD等,叶酸、维生素B12又与同型半胱氨酸的代谢密切相关,本文就三者与NAFLD的关系作一综述,为NAFLD的临床诊疗提供新思路.

Abstract

Nonalcoholic fatty liver disease(NAFLD),a prevalent liver disorder globally,is strongly associated with insulin resistance,obesity,and metabolic syndrome.As individuals grow older,the likelihood of developing metabolic disorders such as hyper-tension,hyperlipidemia,and abnormal glucose metabolism increases gradually.NAFLD,which often lacks noticeable symptoms,tends to be overlooked.Therefore,it is important to identify early and effective diagnostic indicators in order to control the progression of the disease.Homocysteine is a known risk factor for several chronic illnesses,including cardiovascular disease,diabetes,and NAFLD.Folic acid and vitamin B12 play a significant role in the metabolism of homocysteine.This paper examines the correlation between the three factors and NAFLD,and presents novel concepts for potential clinical diagnostic and treatment approaches in the future.

关键词

非酒精性脂肪性肝病/同型半胱氨酸/叶酸/维生素B12

Key words

Non-alcoholic fatty liver disease/Homocysteine/Folic acid/Vitamin B12

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基金项目

吉林省自然科学基金(YDZJ202301ZYTS043)

吉林省自然科学基金(20220203130SF)

吉林省自然科学基金(YDZJ202201ZYTS288)

出版年

2024
国际老年医学杂志
吉林大学

国际老年医学杂志

CSTPCD
影响因子:0.435
ISSN:1674-7593
参考文献量26
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