Diabetic nephropathy(DN)is the primary factor leading to the advancement of end-stage renal disease.Tu-bulointerstitial fibrosis(TIF)is a crucial element that impacts renal function in DN.When exposed to high levels of glucose,the ac-tivation of inflammasomes can trigger cell death pathways,including pyroptosis.This can potentially lead to TIF,which in turn cau-ses the decline of renal function.This article focuses on the pathogenic mechanisms of TIF resulting from DN.This study reviews the potential of blocking pyroptosis to slow down the course of DN,providing a new and promising target for therapeutic intervention in the treatment of DN.
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