摘要
中枢淋巴系统指大脑内的功能性淋巴引流,主要包括分布全脑的胶质淋巴系统以及由脑膜淋巴管、颅神经和颈淋巴通路组成的脑脊液外排途径,其生理功能是将脑组织液中的代谢产物从脑实质引流至深颈部淋巴结从而排出脑外.此外,中枢淋巴系统还参与免疫反应和神经炎症等病理过程的调节.中枢淋巴系统的损伤和功能障碍在与年龄相关的脑功能改变、肿瘤、神经血管疾病、神经退行性疾病和神经炎性疾病等发病机制中起着至关重要的作用.本文介绍了中枢淋巴系统的结构、功能和主要影响因素,对其在阿尔茨海默病等神经退行性疾病的相关研究进展及有待解决的问题和作为潜在临床治疗靶点的应用进行综述.
Abstract
The central lymphatic system comprises the glymphatic system,which is present throughout the brain,and the cerebrospinal fluid drainage route,which includes meningeal lymphatic vessels,cranial nerves,and cervical lymphatic channels.The primary role of this system is to remove metabolic waste products,from the brain tissue and transport them to the deep cervical lymph nodes for disposal.Moreover,the central lymphatic system has a role in controlling immunological responses and pathological processes including neuroinflammation.The central lymphatic system's impairment and malfunction are pivotal in the development of age-related changes in brain function,malignancies,neurovascular disorders,neurodegenerative diseases,and neuroinflammatory diseases.This page provides an overview of the organization,operations,and key determinants of the central lymphatic system.Additionally,it offers a concise summary of the pertinent advancements in research on central nervous system disorders,including Alzheimer's disease,trau-matic brain injury,and stroke.Furthermore,the essay highlights unsolved issues in this field of study and examines the possible prac-tical uses of this information as a target for clinical therapy.
国家科技期刊平台
NSTL
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