摘要
黄芩苷(BA)是从黄芩根部分离出来的黄酮类化合物,具有抗炎、抗氧化、抗凋亡及显著的神经保护作用,且安全性高、副作用小.BA 可用于防治中枢系统疾病所致的认知功能障碍、学习记忆缺陷等.睡眠障碍(SD)常伴随认知功能障碍,BA 可改善上述症状,但机制尚不明确.本文就 BA药理作用及其在 SD 导致的认知功能障碍中的研究进展进行综述,以期为 BA 的开发和利用以及认知功能障碍的中药治疗提供新的思路.
Abstract
Baicalin(BA),a flavonoid extracted from the roots of Scutellaria baicalensis,has significant neuroprotective,anti-inflammatory,antioxidant,and anti-apoptotic properties,with a notable safety profile and low negative effects.BA has been ac-knowledged for its capacity to prevent and cure cognitive deficits and learning impairments linked to illnesses of the central nervous sys-tem.Simultaneously,sleep disorders(SD),which often occur along with cognitive dysfunctions,have shown improvement with BA therapy,but the exact reasons behind this improvement are not yet completely understood.This study presents a comprehensive over-view of the existing pharmacological knowledge on BA and examines its recent progress in treating cognitive deficits.The goal is to pro-vide fresh insights on how to effectively use BA and traditional Chinese medicine for addressing cognitive dysfunctions.
基金项目
国家自然科学基金项目(81860215)
内蒙古自治区卫生健康委医疗卫生科技计划项目(202201400)
国家科技期刊平台
NSTL
万方数据