晚期糖基化终末产物在衰老相关疾病中的研究进展
Research Progress on Advanced Glycation End Products in Aging-related Diseases
沈艳玲 1张云波 2刘承红 1顾申红2
作者信息
- 1. 海南医学院,海口 570000
- 2. 海南医学院第一附属医院全科医学科,海口 570102
- 折叠
摘要
衰老是人类生命体无法避免的自发的生理过程,目前有多种学说阐释衰老的特征,包括氧化应激、蛋白质内稳态失衡、基因稳定性降低、线粒体功能障碍、营养代谢失调等,晚期糖基化终末产物(AGEs)在衰老进程中起关键作用.本文对 AGEs 导致衰老的可能机制,AGEs 与衰老相关疾病如心血管疾病、糖尿病慢性并发症、白内障、阿尔茨海默病、骨质疏松症、肌少症的关系作一综述,为抗衰老研究、药物干预衰老相关疾病和促进老年人健康生活提供新思路.
Abstract
Aging is an inherent physiological phenomenon that occurs throughout human life.Numerous theories have been proposed to elucidate the distinctive features of aging,encompassing oxidative stress,imbalances in protein homeostasis,deterioration of gene stability,mitochondrial dysfunction,and disorders in nutritional metabolism.The role of advanced glycation end products(AGEs)in the aging process is widely acknowledged.This paper aims to examine the potential mechanisms through which AGEs con-tribute to aging,and elucidate the association between AGEs and age-related ailments including cardiovascular diseases,chronic com-plications of diabetes,cataracts,Alzheimer's disease,osteoporosis,and sarcopenia.The objective is to present novel perspectives for anti-aging research,pharmaceutical interventions in age-related diseases,and the promotion of a healthy lifestyle among the elderly.
关键词
晚期糖基化终末产物/晚期糖基化终末产物受体/衰老/衰老相关疾病Key words
Advanced glycation end products/Advanced glycation end products receptor/Aging/Age-related diseases引用本文复制引用
基金项目
海南省重点研发项目(ZDYF2022SHFZ101)
出版年
2024
国家科技期刊平台
NSTL
万方数据