Objective To investigate the value of C-reactive protein to serum albumin ratio(CAR)in evaluating the prog-nosis of elderly patients with acute myeloid leukemia.Methods A retrospective analysis was performed on 84 elderly patients with non-M3 acute myeloid leukemia diagnosed in the Affiliated Hospital of Xuzhou Medical University from February 2018 to December 2022.According to the ROC curve,the optimal cut-off point of CAR was determined,and the patients were divided into a low CAR group and high CAR group.The differences of clinical indexes between the groups were compared.The survival curve was drawn by the Kaplan-Meier method,and the prognostic factors were analyzed by the COX proportional hazard regression model.Results According to ROC,the AUC of CAR was 0.870(95％CI:0.788-0.953,P＜0.05),The optimal cutoff value for CAR was 0.370 as calculat-ed based on the Youden index,with a sensitivity of 86.2％and a specificity of 81.8％.The patients which CAR≤0.370 were the low CAR group and 49 patients with CAR＞0.370 were in the high CAR group.In the high CAR group,the C-reactive protein value was higher(P＜0.05),and the serum albumin value was lower(P＜0.05).The patients in the low CAR group were more likely to a-chieve the first complete remission after induction chemotherapy(P＜0.05).The overall survival and progression-free survival of the low CAR group were better than those of the high CAR group,and the differences were statistically significant(P＜0.05).COX pro-portional hazard regression model showed that CAR was an independent risk factor affecting the prognosis of elderly patients with acute myeloid leukemia(P＜0.05).Conclusion The higher CAR value suggests that the prognosis of elderly patients with non-M3 acute myeloid leukemia is worse,and CAR may be an effective marker for the prognosis rating of such patients.
关键词
急性髓性白血病/C反应白蛋白与血清白蛋白比值/预后
Key words
Acute myeloid leukemia/C-reactive protein to serum albumin ratio/Prognosis
维普
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