Objective To investigate the predictive value of preoperative neutrophil to lymphocyte ratio(NLR),interleu-kin-35(IL-35)and metastasis-associated protein 2(MTA2)for postoperative recurrence and metastasis in patients with prostate canc-er.Methods A total of 160 elderly patients who received prostate cancer surgery in the Second Affiliated Hospital of Hebei North U-niversity from June 2019 to June 2022 were selected as the study subjects and divided into the occurrence group(68 cases)and the non-occurrence group(92 cases)according to the presence or absence of postoperative recurrence or metastasis.The general data of the two groups were compared,and the correlation between NLR,IL-35 and MTA2 and the risk of postoperative recurrence and metas-tasis in patients with prostate cancer was analyzed by logistic regression.ROC curve was used to assess the predictive value of each in-dex for the risk of postoperative recurrence and metastasis in patients with prostate cancer.Results There were significant differences in TNM grade,Gleason score,NLR,IL-35 and MTA2 between the two groups(P＜0.05).Logistic regression analysis showed that NLR,IL-35 levels and MTA2 scores were independent risk factors for postoperative recurrence and metastasis in prostate cancer pa-tients after adjusting for multiple confounders(P＜0.05).ROC curve showed that NLR,IL-35 levels and MTA2 scores had some predictive value for postoperative recurrence and metastasis in prostate cancer patients.Conclusion NLR,IL-35 levels,and MTA2 scores will have predictive value for the recurrence and metastasis of prostate cancer after surgery.They will play an important role in the early identification of high-risk patients for recurrence and metastasis after prostate cancer surgery and in improving patient prognosis.
关键词
中性粒细胞与淋巴细胞比值/白细胞介素-35/转移相关蛋白2/前列腺癌
Key words
Neutrophil to lymphocyte ratio/Interleukin-35/Metastasis-associated protein 2/Prostate cancer
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