摘要
线粒体溶质载体(SLC)是最大的跨膜转运蛋白家族,决定着多种物质交换,包括营养物质、离子、代谢物和药物等.随着人口老龄化的加剧,与增龄相关的肿瘤的发病率逐年上升,SLC25与多种肿瘤的发生发展密切相关,如结肠癌、肺癌、肾癌、膀胱癌等.本文主要对SLC25家族在肿瘤的发生发展中的作用作一综述,为阐明SLC25家族作为老年相关肿瘤治疗靶点的可行性提供理论依据.
Abstract
The mitochondrial solute carrier(SLC)family,the largest group of transmembrane transporters,is essential for the exchange of various substances,including nutrients,ions,metabolites,and drugs.As the population ages,the incidence of age-re-lated tumors is rising.The SLC25 family is particularly linked to the development of numerous cancers,such as colon,lung,kidney,and bladder cancers.This paper reviews the role of the SLC25 family in tumorigenesis,providing a theoretical foundation for evaluating the potential of SLC25 as a therapeutic target for age-related cancers.
基金项目
吉林省自然科学基金(212558JC010486547)
维普
万方数据