Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke
Objective To explore the effects of Sanqitongshu capsule combined with argatroban on neurological deficits and peripheral blood endothelin-1(ET-1),CD41,CD62P and soluble intercellular adhesion molecule-1(sICAM-1)expressions in elderly patients with acute ischemic stroke.Methods A total of 106 elderly patients with acute ischemic stroke from Handan Central Hospital were divided into a study group and a control group according to the random number table method,each had 53 cases.Both groups were given basic treatment,the control group was treated with argatroban,the study group was treated with Sanqitongshu capsule on the basis of the control group.Both groups were treated for 7 days.The clinical efficacy,the National Institutes of Health Stroke Scale(NIHSS)score,hemorheology index,the expression levels of ET-1,CD41,CD62P and sICAM-1 in the two groups before and after treatment,and adverse reactions of the two groups were compared.Results After treatment,the total effective rate of the study group was signifi-cantly higher than that in the control group(P＜0.05).The NIHSS score,plasma fibrinogen level,plasma viscosity,erythrocyte ag-gregation index and the expression levels of ET-1,CD41,CD62P and sICAM-1 in peripheral blood in the two groups were significantly decreased(P＜0.05),and these indicators in the study group were significantly lower than those in the control group(P＜0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P＞0.05).Conclusion Sanqi-tongshu capsule combined with argatroban has a significant effect in the treatment of elderly acute ischemic stroke,it can reduce the de-gree of neurological deficits,and reduce the expressions of ET-1,CD41,CD62P and sICAM-1.
万方数据
维普
