国际老年医学杂志2025,Vol.46Issue(1) :101-104.DOI:10.3969/j.issn.1674-7593.2025.01.020

纳米材料在老年糖尿病创面感染的研究进展

Nanomaterials in wound infeetion care for senile diabetes:current research and developments

刘逸然 白雪 任辉 郭宝锋
国际老年医学杂志2025,Vol.46Issue(1) :101-104.DOI:10.3969/j.issn.1674-7593.2025.01.020

纳米材料在老年糖尿病创面感染的研究进展

Nanomaterials in wound infeetion care for senile diabetes:current research and developments

刘逸然 1白雪 2任辉 1郭宝锋1
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作者信息

  • 1. 吉林大学中日联谊医院整形外科,长春 130033
  • 2. 吉林大学基础医学院病理生理学系,长春 130021
  • 折叠

摘要

老年糖尿病创面感染是糖尿病的严重并发症之一,以糖尿病足溃疡合并感染最为常见.老年人常因自身免疫功能受损、糖尿病病程长等,导致感染创面不易控制从而增加医疗成本、住院时间,以及较高的截肢率、死亡率.因细菌耐药,使用抗生素的临床效果已无法满足老年糖尿病创面感染的治疗需求.新型纳米材料因其具有良好的生物相容性、靶向性、可控释放和低毒性等特点,在抗菌治疗中具有广阔的应用前景.本文对纳米材料在老年糖尿病创面感染的抗菌机制及研究进展作一综述,为老年糖尿病创面感染的治疗打开新视野.

Abstract

Wound infections in elderly diabetic patients represent a severe complication of diabetes,with diabetic foot ulcers being the most common manifestation.Due to impaired immune function and the prolonged course of the disease,elderly patients often struggle to control wound infections,leading to increased medical costs,extended hospital stays,higher rates of amputation and mortal-ity.As bacterial resistance becomes more prevalent,traditional oral or intravenous antibiotics are increasingly ineffective in treating wound infections in elderly diabetic patients.In contrast,emerging nanomaterials offer promising prospects in antibacterial therapy,ow-ing to their superior biocompatibility,targeted action,controlled release,and low toxicity.This article reviews the latest research on the antibacterial mechanisms of nanomaterials and explores their potential as a novel strategy for treating wound infections in elderly diabetic patients.

关键词

老年糖尿病/糖尿病足溃疡/创面感染/纳米材料

Key words

Senile diabetes/Diabetic foot ulcer/Wound infection/Nanomaterials

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出版年

2025
国际老年医学杂志
吉林大学

国际老年医学杂志

影响因子:0.435
ISSN:1674-7593
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