Research Progress on Drug Resistance Mechanism and Antibacterial Drugs of Carbapenem-resistant Gram-negative Bacilli
A class of atypical β-lactam antibiotics with the strongest bactericidal activity and the largest antibacterial spectrum are the carbapenem antibiotics.However,with the widespread use of such antibiotics,Carbapenem-resistant Organisms(CRO)have spread around the world,posing new challenges to the selection of clinical antibiotics.The synthesis of carbapenemase(the most significant),the loss of channel protein,the overexpression of efflux pump,the modification of drug binding sites,and the formation of biofilm are the five features from which the resistance mechanism of carbapenem antibiotics was introduced in this study.In addition,the selection of antibiotics was reviewed to provide a scientific basis for clinical prevention and treatment of CRO
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