Analysis on Clinical Characteristics and Risk Factors of Methicillin-resistant Staphylococcus aureus Isolated by Blood Culture from a Hospital in Nanchong
Objective To investigate clinical characteristics of patients with Methicillin-resistant Staphylococcus aureus(MRSA)isolated from blood culture and explore corresponding risk factors.Methods Techniques to identify independent risk variables,clinical records and experimental data regarding pertinent inpatients from 2017 to 2022 were gathered and statistically examined.Results 49 out of 181 cases showed MRSA positive with an aggregate examination rate of 27.07％and without an evident tendency from 2017 to 2022.Additionally,constituent ratios of 49 MRSA cases in different departments were ranked to get the top three ones(Nephrology 20.41％,Orthopaedics 10.20％and Paediatrics 10.20％).Patients involved were mainly the seniors and males,with bloodstream infection(83.67％)and pulmonary infection(48.98％)accounting for the most in both groups.Of all the 181 isolates from blood culture,none exhibited resistance to vancomycin,linezolid,tigecycline and quinuptine/dafoptin.Concerning antimicrobial susceptibility tests,the MRSA group demonstrated strong resistance to such regular antibiotics as penicillin(100％),erythromycin(87.76％)and clindamycin(73.47％),while Methicillin-sensitive Staphylococcus aureus(MSSA)group was highly resistant only to penicillin(91.67％).After statistical analysis of the quantities of potential risk factors,it was shown that the use of cephalosporin in the past and being older than 15 or 60 were independent risk factors.Conclusion MRSA isolated from blood culture presented multi-drug resistance.Being aged no more than 15 or more than 60 and prior use of cephalosporin functioned as staple impetuses when it comes to MRSA infection.In order to stop MRSA from spreading further,strict regulatory and monitoring measures must be implemented.
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