The Safety of Domestic Amphotericin B Liposome with Different Dosage Regimens in Patients with AIDS Combined with Talaromyces marneffei Infection
Objective To explore the safety of different dosage regimens of domestic amphotericin B liposomes in clinical application,as well as the common adverse drug reactions and their influencing factors.Methods Between January 2017 and December 2022,information about patients with AIDS and Talaromyces marneffei infections at our hospital was gathered.The fundamental data,the impacts of various amphotericin B liposome dose regimens on the blood system,liver and kidney function,potassium concentration,and the factors influencing potassium concentration were examined.Results A total of 50 patients were included.There was no statistically significant difference between the effects of rapid dosing(n=23,≤4d)and slow dosing(n=27,＞4d)on haematology,hepatic and renal function,and potassium ion concentration(P＞0.05).Hypokalemia(76.0％)was the most common adverse reaction.There were no significant differences between the different dosage regimens on the blood system,liver and kidney function and potassium concentration(P＞0.05).Multiple linear regression analysis showed that potassium concentration before administration(P=0.008)was an important factor affecting hypokalemia induced by amphotericin B liposome.Conclusion For domestic amphotericin B liposomes,a rapid dosage regimen can be employed safely to get the therapeutic dose as quickly as possible.The most common adverse reaction is hypokalemia.Potassium concentration before medication is an important factor affecting hypokalemia.
amphotericin B liposomedosage regimenAIDSTalaromyces marneffeiadverse drug reactions
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