Progress on Genetic Information and Biosynthetic Pathways of Glycopeptide and Polyketide Antibiotics of Amycolatopsis
The genus Amycolatopsis produces secondary metabolites like rifamycin and vancomycin,which are widely used in agriculture and medicine.This genus's natural antibiotics'molecular genetics have been thoroughly researched.Due to the rise in antibiotic resistance,finding new drugs to fight infections has become a priority.New advances in understanding the genetic information of metabolites can help rationally manipulate biosynthetic pathways for the development of new natural antibiotics.In this review,we review the recent achievements of glycopeptide and polyketide antibiotics discovered by the Amycolatopis genome sequence and their biosynthetic pathways.
NETL
NSTL
万方数据
