Research Progress in Improving Pleuromutilin Production
Pruromutilin is one of the synthetic precursors of semi-synthetic antibiotics in terpene compounds and is a secondary metabolite produced by large basidiomycetes.The transformation of fungi is relatively complex,and the market demand is constantly expanding,indicating that there are challenges and potential applications coexisting in the improvement of pleuromutilin producing bacteria.In order to better understand pleuromutilin-producing bacteria and serve as a guide for future strain improvement,this article provides an overview of the biosynthetic pathways of pleuromutilin and reviews relevant research on mutation breeding,genetic engineering breeding,and heterologous expression of pleuromutilin producing bacteria.
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