Clinical Distribution and Drug Resistance Analysis of Pseudomonas aeruginosa in a Hospital
Objective A theoretical foundation for the clinical treatment of Pseudomonas aeruginosa(PAE)infection and the prudent use of antibacterial drugs was provided by an analysis of the source and clinical distribution of PAE infection in the last six years at Dalian Friendship Hospital,as well as an examination of the resistance of eleven common clinical antibacterial drugs.Methods Using Whonet 5.6 software,we conducted a retrospective analysis of 1 316 strains of PAE infection from January 2017 to December 2022.We also isolated and cultured bacteria in vitro and conducted drug susceptibility experiments.Finally,we used Spss 23 software to perform a chi-square test on the change in drug resistance rate of this bacterium within three years.Results Among the 1 316 strains of PAE,907 strains(68.9％)of sputum and 167 strains(12.7％)of urine were mainly derived from bronchoalveolar lavage fluid,bile,secretions,etc.These strains were mainly distributed in ICU 513 strains(39.0％)and geriatrics 359 strains(27.3％).Among the 11 antibiotics,the resistance rate of piperacillin/tazobactam,cefepime,and aztreonam changed significantly within 6 years(P＜0.05).The highest resistance rate during this period was levofloxacin in 2021(37.0％),and the lowest resistance rate was cefepime in 2022(8.3％).Conclusion The resistant rates of PAE to carbapenem and quinolones were high.The drug resistance rate of piperacillin/tazobactam increased year by year.The surveillance of drug-resistant bacteria should be strengthened and the management of antibiotics should be strengthened in the clinic.
Pseudomonas aeruginosaclinical distributiondrug resistanceantibioticssurveillance of drug-resistant bacteriamulti-drug resistance
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