Characteristics and Drug Resistance of Klebsiella pneumoniae Infection in a Hospital
Objective To investigate the characteristics and drug resistance changes of Klebsiella pneumoniae infection in the first People's hospital of Qingzhen City from 2015 to 2021,and to provide reference for the control of Klebsiella pneumoniae infection and rational drug use.Methods The identification and drug sensitivity test of Klebsiella pneumoniae were carried out by the Vitek-2 Compact automatic microbial analysis system in Merieux,France.According to the standards of CLSI,Whonet 5.6 and SPSS 25.0 software were used for statistical analysis.Results During the period of 2015 to 2021,a total of 1486 strains of Klebsiella pneumoniae were isolated from a variety of clinical specimens.Of these,91.5％were common strains(CKP)and 8.5％were hypermucoviscous strains(HMKP),which were primarily isolated from specimens related to the lower respiratory tract(82.2％).Patients from the pediatric(20.4％),intensive care unit(19.3％),neurosurgery(15.3％),and respiratory(14.9％)wards were frequently seen there.The detection rates of super-broad spectrum β-lactamase(ESBL)-producing Klebsiella pneumoniae and carbapenem-resistant Klebsiella pneumoniae(CRKP)were 36.2％and 4.1％,respectively.And,the resistance rate of ESBL producing strains to multiple antibiotics was significantly higher than that of non-ESBL strains,and the resistance rate of CKP isolates was significantly higher than that of HMKP isolates(P＜0.05).Furthermore,the drug resistance rate of CRKP to β-lactam antibiotics,quinolones antibiotics,aminoglycosides antibiotics and sulfonamides antibiotics was more than 90.0％.Conclusion Between 2015 and 2021,Klebsiella pneumoniae isolated from the hospital exhibited distinct distribution features and medication resistance,with the latter showing an increasing trend.CRKP isolates are seriously resistant to commonly used clinical antibiotics,and should be rationally selected according to the results of drug sensitivity.Meanwhile,disinfection and isolation measures should be also taken for CRKP infected patients.
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