临床药师参与1例CRKP感染患儿的治疗实践
Clinical Pharmacist's Participation in the Treatment of a Child with Carbapenem Resistant Klebsiella pneumoniae Infection
冯亚男 1谭尧月 1韩倩 1牟鸣1
作者信息
- 1. 达州市中心医院临床药学科,四川 达州 635000
- 折叠
摘要
目的 为耐碳青霉烯肺炎克雷伯菌(CRKP)感染患儿的治疗提供经验参考.方法 临床药师参与1例CRKP肺部、血流感染患儿的抗感染治疗过程.通过查阅文献,结合患儿具体情况及抗菌药物的PK/PD协助医师制定个体化给药方案.结果 参考药师建议,予以替加环素联合美罗培南治疗后,患儿感染得到有效控制,未出现药物相关不良反应.结论 本次治疗,临床药师协助医师进行用药方案调整,改善了治疗效果,对于CRKP感染严重的8岁以上患儿,可考虑采用替加环素联合美罗培南的治疗.
Abstract
Objective To provide experience reference for the treatment of children with carbapenem-resistant Klebsiella pneumoniae(CRKP)infection.Methods The clinical pharmacist participated in the anti-infective treatment of a child with CRKP lung and bloodstream infection.The clinical pharmacist worked with the physician to create customized medication delivery strategies by analyzing the literature,taking into account the unique characteristics of the children,and considering the PK/PD of antibiotics.Results The physician adopted the pharmacist's suggestion and treated the child with tigecycline combined with meropenem.The infection of the child was effectively controlled,and there were no drug-related adverse reactions.Conlusion It is of great significance for clinical treatment for clinical pharmacists to assist physicians in adjusting and optimizing medication regimens.Meropenem plus tigecycline may be used to treat severe CRKP infection in children older than 8 years old.
关键词
耐碳青霉烯肺炎克雷伯菌/儿童/替加环素/美罗培南/延长输注时间/联合用药Key words
carbapenem-resistant Klebsiella pneumoniae/children/tigecycline/meropenem/extend infusion time/drug combination引用本文复制引用
出版年
2024
NETL
NSTL
万方数据