Clinical Distribution Characteristics and Drug Resistance Analysis of 777 Strains of Klebsiella pneumoniae
Objective The clinical distribution characteristics and drug resistance rate of Klebsiella pneumoniae were analyzed to provide an experimental basis for the rational use of antibiotics in the clinic.Methods Clinical information on infected patients of 777 strains of Klebsiella pneumoniae isolated from clinical specimens of Sichuan Armed Police Corps Hospital from January 2018 to December 2022 was collected,including age,gender,department,specimen,date and drug sensitivity test results.Data were analyzed using SPSS 22.0 software.Results 777 strains of Klebsiella pneumoniae were isolated without obvious seasonality,mainly from middle-aged and elderly men.Klebsiella pneumoniae was mainly isolated from the respiratory department(16.99％),mainly from sputum samples(48.13％),ESBLs-producing strains accounted for 21.36％,imipenem resistant strains accounted for 6.63％.The resistance rate of 777 strains of Klebsiella pneumoniae to polycolistin B was the lowest(0),followed by that of tigecycline(0.39％).Amikacin,carbapenase,and piperacillin/tazobactam had drug resistance rates of between 15％and 20.46％,respectively.Cefoperazone/sulbactam,cefoxitin,gentamicin,tobramycin,and ceftazidime had drug resistance rates of 23.48％-29.34％.The resistance rates of 777 strains of Klebsiella pneumoniae to the third and fourth generation of cephalosporin from low to high were ceftazidime,cefepime,ceftriaxone and cefotaxime respectively.Over the past five years,our hospital's drug-resistant Klebsiella pneumoniae strain was greater than the norm for the country and province before 2020,and it was lower in 2021.The medications were resistant to third-generation cephalosporins and carbapenase.Conclusion Drug resistance is directly correlated with the use of therapeutic antibiotics,as evidenced by the fact that the drug resistance rate of Klebsiella pneumoniae at our hospital declines as the number of cases admitted falls.In clinical practice,it is necessary to accurately assess the presence of infection and use accurate drugs to avoid antibiotic misuse.
Klebsiella pneumoniaeclinical distribution characteristicsantimicrobial resistanceextended spectrum betalactamasesantibiotic exposurerational drug use
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