Analysis of Clinical Distribution Characteristics and Antibiotics Resistance Rates of Klebsiella pneumoniae in a Hospital
Objective In order to establish a baseline for the management of nosocomial infections,it is necessary to examine the bacterial dispersion and antibiotic resistance of Klebsiella pneumoniae(KPN)that was isolated from clinical departments at Tai Zhou Hospital of Traditional Chinese Medicine.Methods Clinical specimen sources,department distribution and detection rate of KPN collected from 2020 to 2022 were analyzed.Meanwhile,the drug resistance rates of the strains in 3 years were compared and analyzed.Result A total of 1213 strains of KPN were clinically isolated from 2020 to 2022,among which 134 were carbapenem-resistant Klebsiella pneumoniae strains(CRKP).The detection rates of CRKP strains were 8.2％(28/342),7.4％(30/408)and 16.4％(76/463),respectively.KPN was mainly isolated from sputum samples with a composition ratio of 61.1％(741/1213),followed by urine 19.5％(236/1213),plus 6.3％(77/1213).CRKP strain was the most isolated in sputum samples,with a composition ratio of 47.8％(64/134),followed by urine at 23.9％(32/134),and alveolar lavage fluid at 14.9％(20/134).KPN was detected in the intensive care unit(ICU),respiratory department,neurosurgery department and oncology department,with the proportion of 23.0％(279/1213),16.2％(196/1213),13.6％(165/1213)and 7.8％(95/1213),respectively.The departments with CRKP strain were ICU 44.8％(60/134),neurosurgery 23.9％(32/134,oncology 7.5％(10/134)and thoracic surgery 6.7％(9/134).The resistance rates of carbapenem-sensitive Klebsiella pneumonia strains(CSKP)to ciprofloxacin and levofloxacin were the highest(41.1％and 41.6％).Between 2020 and 2022,there was a rise in the rates of drug resistance to ceftazidime and piperacillin/tazobactam(P＜0.05).The resistance rates of CRKP to imipenem,meropenem,amikacin and cotrimoxazole were 48.5％-98.8％,with no obvious upward trend(P＞0.05).The rates of resistance to other antibiotics were significantly increased(P＜0.00l).In comparison to CSKP strains,CRKP strains exhibited significantly greater rates of resistance to all types of antibiotics;this difference was statistically significant(P＜0.001).Conclusion In order to stop the spread of CRKP,all clinical departments should pay attention as the number of CRKP strains detected in our hospital has increased.
Klebsiella pneumoniaedrug resistance ratecarbapenem-resistancemultiple drug resistanceclinical distribution characteristicsinfection control
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