Recent Advances in the Application of Azole Hybrids to Fight Against Acinetobacter baumannii
The conditionally pathogenic Gram-negative pathogen Acinetobacter baumannii is found in nature and is a serious threat to human health.It can cause a variety of deadly hospital infections,including ventilator-associated pneumonia,urinary tract infections,secondary meningitis,respiratory infections,and bacteremia.Acinetobacter baumannii has already developed resistance to almost all existing antibiotics,but no new anti-Acinetobacter baumannii drugs have been launched for nearly half a century.Therefore,there is an urgent need to develop new drugs against Acinetobacter baumannii.Azoles are widely used in many different medications and can generate a variety of covalent and non-covalent interactions with different bacterial targets.Among them,azole hybrids have the ability to treat a variety of resistant Acinetobacter baumannii infections and have the ability to operate on numerous bacterial sites at once.They may also be able to overcome drug resistance and increase antibacterial effectiveness.This article will summarize the latest research progress on azole hybrids with anti-Acinetobacter baumannii activity developed since 2020,in order to provide theoretical support for the discovery of new drug candidates in the future.
NETL
NSTL
万方数据
