Distribution and Drug Resistance Analysisof Pathogenic Bacteria in Blood Stream Infectionof Hospitalized Patients in a Hospital from 2017 to 2022
Objective In order to improve clinical diagnosis,treatment,and prevention of bloodstream infections(BSIs),we would like to study the distribution and drug resistance of bacteria isolated from BSIs in our hospital.Methods A retrospective study will be conducted to review and analyze clinical and laboratory data from patients with BSIs treated at our institution between January 2017 and December 2022.Results A total of 791 bacterial strains were isolated from 10,012 blood culture samples,including Gram-negative bacteria(334,42.22％),Gram-positive bacteria(361,45.64％)and Candida(14,1.77％).The top 3 isolated bacteria are Escherichia coli(22.25％),CNS(19.6％),and Klebsiella pneumoniae(9.73％).The ESBL detection rates of Escherichia coli and Klebsiella pneumoniae were 44.30％and 22.7％.The carbapenem-resistant Escherichia coli and Klebsiella pneumoniae were 0.6％and 1.3％.The carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa were 93.33％and 6.67％.The prevalence of MRSA and MRCNS were 84.52％and 3.33％.Staphylococcus,Enterococcus,and Streptococcus pneumoniae resistant to vancomycin and linezolid have not been detected yet.Conclusion Escherichia coli was the most common pathogen in bloodstream infections(BSIs)at our hospital,and the ESBL was the primary cause of medication resistance.Escherichia coli and Klebsiella pneumoniae had increased resistance to carbapenem.Clinical attention should be paid to the production of drug-resistant bacteria and rational use of antibiotics.
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